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Postdoctoral Research Associate in Bone Biomechanics

University of Sheffield

Sheffield, United Kingdom

MultiSim is a five-year programme that aims to create a new modelling framework for the human musculoskeletal system.The £6.7M Frontier Engineering grant from the Engineering and Physical Sciences Research Council (EPSRC) – awarded to the world leading and innovative Insigneo Institute – will improve treatments for diseases of the musculoskeletal system.

The post holder will generate a 3D realistic finite element (FE) model of the growing mouse knee joint through in vivo and ex vivo microcomputed Tomography (µCT) imaging. A combination of contrast enhanced µCT, well-established staining methods, novel elastic registration algorithms, and adaptive biomechanical simulations will be used to explore the relation between mechanics and biology on the process of knee joint growth in mice. In addition, a novel mechanoregulation algorithm for bone and cartilage growth will be explored by means of constrained optimisation techniques.

Applicants should hold a PhD in the Life Sciences, Engineering, Physics, Biology or related disciplines and be familiar with finite element modelling (Ansys/Abaqus), µCT imaging, and the biomechanics of the mouse knee joint.

The post is full time for one year and will report to Dr Mario Giorgi and Dr Enrico Dall’Ara, Department of Human Metabolism, The University of Sheffield.

You can view the supporting documentation by clicking on About the Job and About the University located near the top of your screen.

Main Duties and Responsibilities
 Generate a 3D FE model (including its articular cartilage) of the mouse knee joint capable of growing over time as observed experimentally.
 Interact with other researchers and academics on the MultiSim project;
 Integrate with the MultiSim Multiscale framework.
 Interact with other early stage researchers and experienced researchers within the INSIGNEO Institute, the rest of the university and the institution our partners in collaborative projects.
 Write papers that are published in internationally peer-reviewed journals.
 Present work at National and International conferences.
 Maintain up-to-date knowledge of the relevant literature.
 Self-organise time to ensure the achievement of the objectives agreed with the group leader, and to continue to develop his/her knowledge in the domain of research.
 Effectively collaborate with colleagues, co-workers, partners, etc. to achieve the agreed objectives.
 Write technical reports both for internal monitoring and for reporting to external funding agencies.
 Make a full and active contribution to the principles of the “Sheffield Academic”. These include the achievement of excellence in applied teaching and research, and scholarly pursuits to make a genuine difference in the subject area and to the University’s achievements as a whole.
 Any other duties, commensurate with the grade of the post.

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