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Research Associate in Experimental Biomechanics

University of Sheffield

Sheffield, United Kingdom

Mechanical Engineering has been a major discipline in the University since its foundation in 1905. According to the most recent Research Assessment Exercise, the Department is in the Top 5 in the UK in the league table of Mechanical Engineering departments. We have over 80 members of academic and research staff, who, along with more than 100 PhD students, carry
out cutting-edge research spanning both fundamental science and industrial applications.

The INSIGNEO Institute for in silico Medicine is an initiative between the Faculty of Engineering and the Faculty of Medicine at the University of Sheffield and the Sheffield Teaching Hospitals Foundation Trust. INSIGNEO intends to realise the scientific ambition behind the Virtual Physiological Human, producing a transformational impact on healthcare. While recently established, INSIGNEO is already considered one of worldwide-leading institutions in the area of in silico medicine research.

This is an excellent research opportunity within the integrated musculoskeletal biomechanics (IMSB) group of the INSIGNEO Institute for in silico Medicine and to contribute to the activities of the newly established Sheffield NIHR Biomedical Research Centre (BRC) for Translational Neurosciences.

Translational Neuroscience is the discovery pathway that develops basic findings, related to neurological diseases, into new effective treatments. This pathway extends from research into underlying disease mechanisms, through the process of identifying key molecular changes leading to disease (target identification) and screening for drugs that correct the problem (lead compound identification), to testing of promising compounds in clinical trials. Within this framework, the post-holder will contribute to develop and deploy ad-hoc experimental protocols for the identification of biomarkers for the
quantification of a patient’s neuromusculoskeletal function and response to treatment in various neuro-degenerative diseases (Motor Neuron Disease, Parkinson’s disease, Multiple Sclerosis and stroke). These protocols will be based on measurements selected among those coming from wearable sensors, stereophotogrammetric systems, isokinetic dynamometers, and
lectromyography. The post holder would also collaborate with specialists in medical imaging and in silico medicine within the Insigneo institute to the development of subject-specific models, which can provide biomarkers
that are difficult or impossible to measure experimentally

You can view the supporting documentation by clicking on About the Job and About the University located near the top of your screen.

Main Duties and Responsibilities
• Develop original experimental protocols for the quantification of an individual neuromuscular function within a daily clinical setting;
• Support the biomechanics data collection sessions, based on the above protocols, that will be performed within the BRC;
• Establish and perform quality insurance checks on the data collected from various instruments, including Inertial sensors, dynamometers, stereophotogrammetry, EMG, and MRI;
• Establish rigorous data processing techniques to extract relevant biomarkers from the analysis the data coming from previous studies and/or collected during the above experiments;
• Collaborate closely with medical imaging and in silico medicine experts to the development of subject-specific models;
• Be actively engaged and participate to all meetings and activities in the collaborative projects in which the IMSB group at INSIGNEO is currently participating;
• Interact with other early stage researchers and experienced researchers within the INSIGNEO Institute, the rest of the university and the institution our partners in collaborative projects;
• Maintain up-to-date knowledge of the relevant literature;
• Present work at international conferences;
• Write papers that are published in internationally peer-reviewed journals;
• Write technical reports both for internal monitoring and for reporting to external funding agencies;
• Effectively collaborate with colleagues, co-workers, partners, etc. to achieve the agreed objectives;
• Self-organise time to ensure the achievement of the objectives agreed with the group leader,
• Carry out project-oriented management, for example co-ordinating resources to meet the research deliverables.
• Carry out administrative roles as required.
• Lead and manage specific aspects of project work, for example leading on project tasks and writing project deliverables
• Provide input to the strategy and research direction of the project and wider research area.
• Any other duties, commensurate with the grade of the post.

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