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Postdoctoral Research Associate

University of Sheffield

Sheffield, United Kingdom

We are seeking a highly motivated scientist to work on an Arthritis Research UK funded project entitled “An epigenetic approach to healthy ageing; modulating cellular senescence in stem cells”. The main focus of this post is to investigate the effects of a small molecule, which is able to reverse senescence in mesenchymal stem cells through an epigenetic mechanism and determine whether this leads to improved health span using in vivo models of ageing, particularly in the musculoskeletal system.

This is an exciting opportunity for a researcher to develop their scientific career by working as part of a highly productive team in an outstanding research environment situated in CIMA.

You will use in vitro and in vivo stem cell systems and systems to assess tissue ageing and function and whether these can be ameliorated by modulation with small molecules interfering with epigenetic regulators. A proven academic track record and a commitment to a career in this area of research are essential. Experience in mesenchymal stem cells, epigenetics, and/or possession of a personal Home Office license are an advantage.

This post is full time and fixed term for 16 months.

You can view the supporting documentation by clicking on About the Job and About the University located near the top of your screen.

Main Duties and Responsibilities
 Work independently but liaise closely with the other members of the research team to generate high quality research output.
 Keep exemplary research records in accordance with the local guidelines, ensuring that the experimental records are up to date and regularly signed off by the line manager.
 Be responsible for administrative tasks that directly relate to their research project in compliance with HO and ethical regulations and undertake a small amount of administrative work in support of the needs of the Academic Unit and the Department of Oncology and Metabolism.
Planning and Organising
 Assume responsibility for carrying out specified research objectives whilst also contributing to the other projects incorporated in the programme.
 Design, carry out, develop and refine experiments in order to obtain reliable data.
 Play an active role in the management group that oversees grant progress and contribute significantly to the scientific discussion and development of the projects included in the programme.
 Be responsible for planning own research, devising short-term and longer term research plans and targets, and agree a timeline for completing the work with the management group.
 Demonstrate ability to take initiative and independent scientific thinking, whilst contributing to the success of the team.
 Prepare high-quality research presentations, posters, reports and publications.
 Contribute to writing grant applications to obtain research funding, and to develop research collaborations, locally, nationally and internationally.
 Demonstrate ability to complete high quality work to set deadlines.
 Be willing to adopt some degree of flexible working practices as/when this is required to complete specific research tasks.
 Supervise undergraduate and postgraduate students in their day-today activities


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