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Postdoctoral Research Associate in Drug Repurposing

University of Sheffield

Sheffield, United Kingdom

Summary: As part of the international CureAD-CIRCUITS consortium, you will drive discovery of drug targeting for genes and processes directly involved in Alzheimer’s disease progression. You will drive drug targeting for the most likely functional interactions between selected regulatory target genes and processes, drug interventions and disease outcomes. You will validate your predictions using collaborators’ cellular models and assay readouts.

You will work closely with our multidisciplinary research group to apply and validate interpretation of drug induced response signatures using bioinformatics-based approaches. This innovative opportunity will exploit your skills in drug repurposing, showcasing your ability to integrate datasets and interpret drug response signatures. There will be opportunities for training and travelling to local and international meetings, and close collaboration with the groups in Cambridge, USA and Sheffield departments of Computer Science and Neuroscience. You understand the need for translation and are a highly independent researcher who wants to exploit your interest in rapid predictive approaches to drug discovery. This is a career launching post and comes at a time when the skills you will acquire will be in high demand in both academia and industry. Working in a stimulating environment in close association with collaborators at Harvard, MIT and the Whitehead Institute, together with clinical and wet lab scientists, you will join a growing team in the Centre for Genome Translation working across Sheffield University’s Institute for Translational Neuroscience in the Neuroscience and Computer Science departments.

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