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Postdoctoral Research Associate

University of Sheffield

Sheffield, United Kingdom

Summary: The successful candidate will work in the Department of Oncology & Metabolism at the University of Sheffield and will be responsible to the group head, Professor Claire Lewis, and her clinical collaborator who is co-leading this study, Professor Janet Brown. Research interests of Professor Lewis’ team include investigations into the role of various macrophage subsets in the relapse of primary and metastatic tumours after various frontline forms of therapy (see: Hughes et al. 2015. Cancer Res; De Palma & Lewis 2013. Cancer Cell; Lewis et al. 2016.

Cancer Cell). This PCUK-funded study will investigate the ability of targeted liposomes to eliminate relapse-promoting, perivascular macrophages in mouse prostate tumours. We hope that this exciting project will lead on to a clinical trial of this new treatment in combination with hormone therapy, radiation therapy or chemotherapy for men with prostate cancer. You will hold a good degree and PhD and have experience in cell culture, FACS and flow cytometry, immunohistochemistry and/or immunofluorescence microscopy, RNA/protein isolation and analysis and the use of mouse tumour models (including the harvesting/analysis of body tissues and fluids for analysis).


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